Peptide therapeutic agents that block signal transduction mediated by protein-protein interaction, fused with fuctional penetrating peptide
A key factor in innate and adaptive immunity
Discovered in 2011 by Bruce A, Beautler et al (Nobel Prize awarded)
Disease induction via abnormal (autoimmune) and excessive (inflammatory) response
Is known to take part in Lupus, Rheumatoid Arthritis, Psoriasis, etc.
Suppressing Pan-TLR signal transduction by blocking intracellular protein-protein interaction
comprised of Cell-Penetrating Peptide and TIRAP-derived amino acid sequences (TIRAP:Toll/Interleukin-1 Receptor domain-containing Adaptor Protein)
TLR Decoy Peptide