The full name of Lupus is Systemic Lupus Erythematosus, and it is an autoimmune disease that occurs primarily in young ages including women of childbearing age. Autoimmunity is a symptom where one’s immune system malfunctions and attacks his or her own body instead of protecting it from the external environment. This leads to systemic inflammatory reactions, including skin, joint, kidney, lung, neurons, and more. Lupus progresses chronically with degeneration and alleviation occuring repeatedly.
Symptoms in the skin are most commonly observed. About 80~90% of the patients undergo skin diseases such as cheek and discoid rashes, photosensitivity, and canker sore.
Joint pain is another common symptom that occurs in more than 75% of the patients. Some patients show only joint pain, without other symptoms of typical arthritis such as defect in joint movement, edema, hot flush, or rash.
The disease is found in 25~75% of the patients with renal disease, without self-awareness before renal failure or nephrotic syndrome outbreaks.
Joints that connect bones are surrounded by thin synovial membrane that produces synovia. Rheumatoid Arthritis(RA) is a chronic, inflammatory systemic disease that features consistent inflammatory reactions of the synovial membrane.
The main clinical features are joint destruction and malfunction, led by impairment of joint cartilage and bone ulceration due to continuous, chronic inflammation of the synovial membrane.
RA is the second most abundant of chronic arthritis after osteoarthritis, and the most common cause of inflammatory arthritis.
The most common ages affected by this disease are from 35 to 50, with women 3 times more prone than men. Without proper treatment, the patient undergoes impairment in daily life 10 years after pathogenesis. The pain, grinch, and depression caused by it impoverish the patient’s quality of life, as well as arousing serious social and economical loss.
Psoriasis is a disease that features ulerythema covered with silver-white exfoliation that have distinct boundaries. It occurs in frequently stimulated body parts such as elbow, knees, hips, and scalp. Various clinical features from small papules to squamous pustular psoriasis, psoriatic arthritis appear.
Erythematosus is a symptom that blushes skins, and exfoliation is a symptom with white corneous arousal. Psoriasis is distinguishable by erythematosus and exfoliation in thickened skin.
Recently the cause of psoriasis was discovered as disorders in immune system. It was also found that not only diseases in the skin but also psoriatic arthrisis, which leads to secondary complications like metabolic syndrome, acute cardiac infarction, and stroke, could be accompanied.
Professor Sang-Don Choi of Ajou University
Professor Sang-Won Lee of Shinchon Severance Hospital
Lupus Therapeutics US Development Status